The Science Behind CONTRAVE®

CONTRAVE® is a prescription-only, FDA-approved weight-loss pill believed to work on two areas of your brain—the hunger center and the reward system—to reduce hunger and help control cravings.CONTRAVE(R) may help adults who are obese or overweight (with a weight-related medical problem) lose weight and keep it off. CONTRAVE contains two medicines, bupropion and naltrexone. These well-known drugs have been prescribed separately for years—bupropion for depression and smoking cessation, and naltrexone for alcohol and opioid dependence.2

The mesolimbic reward system to help control cravings


The hypothalamus (hunger center) to reduce hunger


CONTRAVE has a well-studied safety and tolerability profile. Three long-term (56 weeks) studies have shown that patients who add CONTRAVE lose approximately 2 to 4 times more weight than with diet and exercise alone.3

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1The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.
2The individual components of CONTRAVE are not approved for weight loss. CONTRAVE is not approved to treat depression or other mental illnesses, alcohol or opioid dependency, or to help people quit smoking.
3Across three 56-week studies, 46% of patients on CONTRAVE lost 5% or more body weight (vs 23% of patients on placebo). Results may vary.

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